Etiology:
Hypertriglyceridemia, Malignant monoclonal gammopathies, IVIG etc.
Plasma triglycerides (g/L) x 0.002 = mEq/L ↓ in Na+
Plasma proteins – 8 (g/L) x 0.025 = mEq/L ↓ in Na+
Corrected Sodium (In hyperglycemia)
Sodium measured + 0.016x(Glucose - 100)
Katz formula from 1973
When hyperglycemia registers, ECF osmolality rises above that of ICF and glucose enters the cell displacing water into the ECF. This translates in a depletion of cellular water and a serum Na concentration falling in proportion to the ECF dilution. This decrease is said to be of 1.6 mEq/L for every 100 mg/dL increase in plasma glucose levels above normal.
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