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Natriuretic peptides

  • Elevated in HF, CAD, valvular HD, pulmonary HTN & sepsis.
  • BNP (vasoactive peptide) has a shorter 1/2 life than NT-proBNP (inactive) which tends to circulate longer & can detect earlier forms of HF.
  • In CKD, ↓GFR is associated with ↑ BNP & ↑↑ NT-proBNP.

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