- Elevated in HF, CAD, valvular HD, pulmonary HTN & sepsis.
- BNP (vasoactive peptide) has a shorter 1/2 life than NT-proBNP (inactive) which tends to circulate longer & can detect earlier forms of HF.
- In CKD, ↓GFR is associated with ↑ BNP & ↑↑ NT-proBNP.
